[Colloq] Reminder: PhD Thesis Proposal - TODAY - 12noon, Wenxu Tong

[Rachel Kalweit]

College of Computer and Information Science
presents a PhD Thesis Proposal by:
Wenxu Tong

Title:
Using the POOL method with THEMATICS for protein active site
prediction


Tuesday, November 7, 2006
12:00pm
366 West Village H

Abstract:

Protein active site prediction is a very important problem in
bioinformatics.  THEMATICS is a simple and effective method based on the
special electrostatic properties of ionizable residues to make the
prediction from protein structure alone.  The process involves
distinguishing titration curves with perturbed shape from normal ones
and it is subtle in many cases.  We propose Partial Order Optimal
Likelihood (POOL), a novel method, to estimate for each residue the
probability that it lies in an active site.  This method makes use of
prior monotonicity assumptions on the multidimensional feature space and
leads to a convex optimization problem.  The goal of this research is to
build a good learning system to automate protein active site prediction
using a combination of THEMATICS and other potentially useful features.

Thesis advisor:  Ronald J. Williams
Committee: Javed A. Aslam
             Robert Futrelle
             Mary J. Ondrechen

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